Why Reprogramming is Inefficient

Monday, November 26, 2012

By studying the first 48 hours of stem cell reprogramming—in which adult somatic cells are converted into induced pluripotent stem cells (iPSCs)—researchers have identified some barriers to the process and one potential way to boost speed and efficiency early on. For now, the process is not very efficient: Only about one out of every 1000 human somatic cells wind up becoming iPSCs, and the process of conversion can take about a month. “[The finding] was thrilling, and we didn’t expect it at all,” said lead investigator Kenneth Zaret, PhD, associate director of the Penn Institute for Regenerative Medicine and Professor of cell and development, in BioTechniques NewsClick here for full article.