About the Penn Institute for Regenerative Medicine (IRM)

Established in 2007, Penn’s Institute for Regenerative Medicine (IRM) was formed to promote basic discoveries in stem cell biology and regeneration, and to translate those discoveries into new therapies that may alleviate suffering and disease.  Researchers at the IRM seek an understanding of how cells and tissues are formed as well as how they can be repaired or replaced when damaged or lost due to injury, disease or aging.  This field of medicine is called regenerative medicine.

As a University-wide institute created through the Provost’s office, the IRM promotes the integration and collaboration of researchers from many schools including:

   • School of Medicine
   • School of Veterinary Medicine
   • School of Engineering and Applied Science
   • School of Arts and Sciences
   • School of Dental Medicine
   • Public Outreach and Education Programs

Additionally, some members of the IRM are investigators at the Wistar Institute and Children’s Hospital of Philadelphia.

Fostering Innovation

What differentiates the Penn IRM from other regenerative medicine and stem cell
institutes in the United States are the innovative collaborations between faculty and
staff from all areas within the university. The strength in Penn’s program lies in the
unique environment that brings together experts from many disciplines working toward
a common goal.

Pioneering Research

Stem cell and regenerative biology research is essential to the future of medicine, so that physicians and scientists can work to translate these discoveries into clinical treatments for patients.

One day, stem cells may be used in treatments for:

   • Reproductive medicine
   • Liver and digestive organ failure
   • Skin burns and wounds
   • Lung disease
   • Cardiovascular disease
   • Tissue and organ replacement

Discoveries made today will pave the way for future discoveries, future therapies and future cures in medicine.

Discoveries like:

   • The identification of key factors crucial to skin regeneration and wound healing
   • The genetic formation of the heart and its vessels that will us help better understand
      congenital heart disease
   • Understanding the embryonic cell signals for liver organ development so that new liver tissue
      can be rebuilt and transplanted

These are some examples of the innovative research accomplished by investigators and faculty at Penn. Together with the support from disciplines across the University of Pennsylvania, their dedication to research and regenerative medicine may one day enhance the quality of life for people
who suffer from some of the most devastating diseases of our time.